The geoscientific data presented in this paper are a foundation for experimental and exploration geological research in the western Wabigoon and southern Abitibi subprovinces of the Superior Province in Ontario, Canada.New geological interpretations, in map and GIS formats, along with compiled mineral deposit information, structural databases, magn
Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy
The RAS-RAF-MEK-ERK signaling pathway (MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers.As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosis, which makes their inhibition an attractive antit